How Should Metformin Be Taken—Before or After Meals?

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Metformin hcl 500 mg should generally be taken with meals, not before or after, to reduce the risk of gastrointestinal side effects like nausea, bloating, or diarrhea. Taking it during a meal helps slow the absorption of the drug, making it easier on your stomach.
If you're prescribed Metformin once daily, it's best to take it with your largest meal, usually dinner. If you're taking it twice or three times a day, each dose should be taken with breakfast, lunch, or dinner accordingly.
There are also extended-release (XR) forms of Metformin available. These are usually taken once daily with the evening meal and tend to cause fewer stomach issues.
Consistency is key—try to take your medication around the same times each day and always follow your doctor’s instructions. Never take Metformin on an empty stomach unless specifically advised by your healthcare provider, as it may increase the risk of stomach upset.
Also, avoid alcohol while on Metformin, as it can increase the risk of lactic acidosis, a rare but serious side effect.
In summary: Take Metformin with meals to minimize side effects and enhance effectiveness. Always follow your prescribed schedule and speak to your doctor if you're unsure.

For more info.  Dosepharmacy

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